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　雖然我們體內(nèi)的許多細(xì)胞可以積累致癌突變，但這些事件中的大多數(shù)不會(huì)導(dǎo)致腫瘤形成，因?yàn)檫@些異常細(xì)胞被防御機(jī)制消除。相反，當(dāng)突變發(fā)生在對(duì)其特異性敏感的特定細(xì)胞類型中時(shí)

單細(xì)胞mRNA測(cè)序(scRNA-seq)允許分析異質(zhì)細(xì)胞群，提供解決各種生物和醫(yī)學(xué)問(wèn)題的令人興奮的可能性。最近開(kāi)發(fā)了一系列方法，因此有必要系統(tǒng)地比較它們的靈敏度，準(zhǔn)確度，精度和成本效

Single-cell mRNA sequencing (scRNA-seq) allows to profile heterogeneous cell populations, offering exciting possibilities to tackle a variety of biological and medical questions. A range of methods has been recently developed, making it nece

To treat and prevent pregnancy-related disorders, researchers must understand not only what can go wrong, but when. Complications, such as preeclampsia and pre-term birth, often occur in the second or third trimester, and most research to da

為了治療和預(yù)防與妊娠有關(guān)的疾病，研究人員不僅要了解可能出現(xiàn)的問(wèn)題，還要了解何時(shí)出錯(cuò)。并發(fā)癥如先兆子癇和早產(chǎn)，通常發(fā)生在妊娠中期或妊娠晚期，迄今為止的大多數(shù)研究都集

單細(xì)胞RNA-seq揭示了細(xì)胞群中固有的細(xì)胞異質(zhì)性，這在許多臨床和研究應(yīng)用中非常重要。

Single-cell RNA-seq reveals the cellular heterogeneity inherent in the population of cells, which is very important in many clinical and research applications. Recent advances in droplet microfluidics have achieved the automatic isolation, l

　　Drop-seq is a technology we developed to enable biologists to analyze RNA expression genome-wide in thousands of individual cells at once. We first described this in a 2015 paper in Cell. Though commercial implementations of droplet-